Trailing fourth-placed Tottenham Hotspur by two points, the Blues realistically must win their final two matches to put their London rivals - and Liverpool, who are one point better off - under pressure.
That result extended the Blues' winning run across all competitions to five matches, which is the flawless run of form to take into a massive last two games.
Huddersfield, meanwhile, is in danger of relegation as it enters Wednesday in 17th place in the table, just three points clear of the drop zone.
Ahead of the match, we took a look at some key battles that could have a major impact on the final result...
Currently in fifth place, Chelsea's attempt to salvage a troubled season by finishing in the top four is now out of their hands heading into the final game of the season at Newcastle this weekend.
However, Wise, who captained Chelsea during his 11 years with the club, does not think late-season success can reconcile the differences between Conte and the Blues hierarchy.
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Three weeks before, Ream had been convicted of first-degree murder in Zarzycki's death but had not yet been sentenced. The FBI and other agencies are digging in a forest in Macomb Township for the remains of 12-year-old Kimberly King.
Huddersfield have failed to score in 20 of their 36 Premier League games this season.
Michael Owen is backing Chelsea FC to beat Huddersfield Town at Stamford Bridge to keep their top-four hopes alive.
With the solitary point from Wednesday game, Chelsea have 70 points from 37 games.
The Reds' Champions League run began in the qualifying play-off last August and they had navigated the entire competition without defeat until two late goals in Rome consigned them to a 4-2 loss on the night.
Manchester City moved onto 97 points with their win over Mat Ryan's Brighton, which is two more than Chelsea's final total from the 2004-05 season, and 105 goals, two more than Chelsea's previous record haul from the 2009-10 season.
"For me personally, and for us as a football club, to secure our status, I've said this before, is for me bigger than the achievement of promotion last season".
Unbeaten in their last six matches, Chelsea have tipped their outlook upside down following a slump which saw them lose five of seven league fixtures.