The Citizens have been largely unstoppable in this season's triumphant league campaign, but the Reds have beaten them three times in 2018.
Southampton defender Wesley Hoedt came closest to opening the scoring before the break when he hit the crossbar in the eighth minute, while Dusan Tadic nearly settled the match in the hosts' favour before Brazil striker Jesus signed off ahead of the World Cup with a thrilling last-gasp salvo. Guardiola's wild celebration with his backroom staff showed what it meant to the Spaniard for City to achieve yet another astonishing feat.
I don't have words - 100 points, 50 points at home, 50 points away, incredible. "In training Pep always seeks to make clear the solutions for each move, regardless of position, they are standard moves, which helps you a lot when improvising".
He said: "I think both teams want to attack - Tottenham as well". We have done that all season.
Their football has been delicious to feast on this season and, even though they've already won the league, the Citizens still have something to play for.
100 - Despite winning six previous league titles across spells at Barcelona and Bayern Munich, Guardiola has reached 100 points in a season for the first time in his career - surpassing 99 with Barca in 2009-10.
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As to clarity of whether Wayne is leaving or staying I'll find out when he comes in for training today. Asked about planning for next season, the manager replied: "I've already done it".
"Numbers are numbers, they are the effect of the way we played".
He said: "We will try to win the game. All the records we broke, it's a effect of the way we played".
Southampton stays up with a win or draw, while they can also lose and likely still survive. But they had no intention of letting the impending party distract them on the south-coast.
Stephens' fellow centre-back Hoedt then headed Tadic's corner against the bar amid an ambling start from the champions.
Guardiola's men pushed hard in the second half and Raheem Sterling struck the righthand post with a deflected effort before John Stones' header from the resultant corner was tipped over by Alex McCarthy.
Swansea manager Carlos Carvahal and players wear a dejected look after their relegation from the Premier League.