TEAM NEWS Portugal made three changes to their line-up for Saturday's World Cup last-16 game against Uruguay, with Bernardo, Goncalo Guedes and Ricardo Pereira all starting for the European champions.
The Paris St Germain forward struck in each half, heading home early on before restoring Uruguay's lead seven minutes after Portugal defender Pepe had levelled.
But Uruguay were back in front seven minutes later when Rodrigo Betancur allowed Cavani to brilliantly curl home his 45th global goal.
2 minutes of Stoppage time!
Uruguay and France don't play until Friday, giving the 31-year-old almost a week to get fit, though his country will be nervously waiting for the results of medical scans.
Despite being one of just five teams to have won the World Cup a few times and boasting two of the finest strikers in European soccer in its attack, Uruguay flew under most people's radar heading into the World Cup.
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How Godin and Gimenez fare against Ronaldo is one of the intriguing subplots surrounding this fixture, though both sides' defensive records have some fearing a tiresome contest. Their style may not be pretty but it is most certainly effective.
Portugal take on Uruguay in the second round of the FIFA World Cup on Saturday.
Portugal, who won Euro 2016 in France, dominated possession but their attack did not have enough bite to break through the Uruguay defence twice, leaving captain Cristiano Ronaldo a frustrated figure during the entire match.
Uruguay got off to a flying start, with Edinson Cavani scoring after just seven minutes, putting pressure on Ronaldo's side nearly immediately. As Argentina's exit proved, one man can only do so much.
But they were level for just seven minutes as Cavani swept home a sensational victor.
One wouldn't be surprised to see the 33-year-old still playing in 2022 but, in all likelihood, his boots will have been hung up by that point.
20 minute: Free-kick to Uruguay Suarez goes down after a challenge from Raphael Guerreiro.