Federer was set to play Jan-Lennard Struff of Germany and Williams faced Kristina Mladenovic of France as they continue their quests for a ninth and eighth Wimbledon title, respectively. The eight-time champion is yet to drop a set this week, and in fact has won his last 27 sets at the championships.
Japan's casual wear company Uniqlo have signed Federer up in reported $30 million per year deal and might have hoped for a longer debut than the one hour 19 minutes it took their man to demolish Lajovic. Next, an uncontrolled effort from Lacko gave a 4-3 advantage to the 36-year-old Swiss.
He followed that up by winning all 20 of his service points in the second set to take it by the same game score.
Eight-time Wimbledon victor Federer told BBC Sport: "I think I played very well".
In total, he lost just nine of 61 points on his serve and broke Lacko five times, including with a dynamic forehand victor to close out the match. Can Federer pull off another straight-set victory?
The third set was one-way traffic. I have to come out there and do the best that I can do.
"I fought as hard as I could".
"I told myself I was not going to lose this match, I had so many match points, I forgot it and started over", Makarova said.
World Cup to stay in Europe following Brazil's elimination
Croatia haven't got bundles of pace in their team and Russian Federation will be hard to beat, just like they were against Spain. All the Swedes in the world are proud of our national team and they will continue to be proud, regardless of how it goes.
"I always have this sort of dream, I just want to walk past them and speak to these people to hear their stories". There may be major tests ahead, and perhaps she might fall short, but what her rivals have witnessed so far is a masterclass in how to get the W by your name.
And the number of remaining top-10 seeds is down to two after No. 9 Venus and No. 10 Madison Keys - beaten 7-5, 5-7, 6-4 Friday by Evgeniya Rodina, a qualifier ranked only 120th - were sent home.
Seven-time champion Serena Williams faced little resistance in her progress to the third round as she overpowered Bulgarian qualifier Viktoriya Tomova 6-1, 6-4.
Marin Cilic briefly resumed his match with Guido Pella on No. 1 Court, but another shower saw them depart with the third-seeded Croatian leading 6-3, 6-1, 3-4 - a break down in the third set. Isner next plays No. 31 Stefanos Tsitsipas, the first Greek man into the round of 16 at a Grand Slam tournament in the 50-year professional era.
Romanian 29th seed Mihaela Buzarnescu thrashed British teenager Katie Swan, 6-0, 6-3 to extend her remarkable renaissance. In the morning, Victoria Azarenka, who has a one-year-old son, lost to the seventh seed, Karolina Pliskova.
Venus next faces Dutch 20th seed Kiki Bertens, who beat Russian world number 107 Anna Blinkova 6-4, 6-0.
Milos Raonic, the 2016 runner-up, is also through to the third round after winning three tie-breaks against John Millman.