In the women's section, meanwhile, Serena Williams returns after missing Wimbledon previous year while she was pregnant.
While his game is ideal to the tee, the tennis star recently recalled an embarrassing wardrobe malfunction episode during his 2007 Wimbledon win and even went on to call it his funniest moment in tennis.
"I think I don't play so many rallies. It's a big deal", said Federer on returning to Centre Court and who is marking the 15th anniversary of his first Wimbledon title in 2003.
"I was excited to wear Uniqlo today, I must tell you", Federer, who signed his initial contract with Nike in 1997 and had been wearing the brand ever since, said after his win.
The Federer first serve was already firing, the world number two dropping just three points on it in the first two sets. He will be the first man in the Open era to play the singles tournament at Wimbledon for a 20th straight year.
Speaking to the press post-match the 36-year-old confirmed that he does not now have a footwear deal and that he is exploring his options, of which Nike remains one.
Southgate tells England stars: ‘Be bigger than 1966 heroes’
Even at Wimbledon, the home of lawn tennis, updates of England's goals were spread by fans watching or listening to the match on their cell phones.
The second-seeded Dane has never been past the round of 16 at the All England Club but showed good form on grass by winning her second title on the surface at Eastbourne last week.
Hey everyone. It is with a heavy heart that I'm announcing that I'll be withdrawing from Wimbledon this year.
He was even dragged into a discussion on Sunday over whether or not he and Nadal - 10 years after their epic All England Club final - could be likened to Lionel Messi and Cristiano Ronaldo. "I guess there's some similarities there as well".
This is only her fourth tournament back after giving birth last September, but on this evidence she will be feared by the top seeds, with fifth seed Elina Svitolina her likely third-round opponent.
The second seeded Caroline Wozniacki of Denmark defeated America's Varvara Lepchenko 6/0, 6/3 to advance to the second round. But Williams wasn't down for long - she won the match in three sets.GLYN KIRK/AFP/Getty ImagesHEAD GAMESSwitzerland's Stan Wawrinka gets frustrated while playing Bulgaria's Grigor Dimitrov.
Five-time champion Venus Williams advanced to the second round at Wimbledon with a 6-7 (3), 6-2, 6-1 victory over Johanna Larsson.