The 30-year-old German remains on course after booking the seventh Grand Slam semi-final berth of her career.
After a insane and awesome final game Angelique Kerber, the only player to reach at least the quarter-final stage in each of the Grand Slams this season, reached the seventh major semifinal as she beat Daria Kasatkina for the fourth time in her career in seven meetings.
With Ostapenko and her compatriot Ernests Gulbis both making the second week at Wimbledon this fortnight, it's the first time in history that multiple Latvian players have made it this far at the same Grand Slam.
Serena Williams is set to resume her quest for an eighth Wimbledon title when the women's quarterfinals get underway at 1:00 p.m. on Tuesday.
"I was down in the first set but I kept fighting". Ostapenko threw four more errors into her next service game to hand the German the first set.
"It really messed with me, then I tried to just calm down, to play my game". "These are the matches I was working for as a kid and to be in the final at Wimbledon is great".
Seeded 11th, Kerber seems to be approaching something close to her 2016 peak, when she won her two grand slam titles and reached the final at Wimbledon.
Ostapenko, 21, was certainly in step on Court One as she blasted a stunning 32 winners.
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"I think the opponent played quite well in the beginning".
German 11th seed Kerber, the highest seeded player left in the women's field, is targeting a maiden appearance in the Wimbledon final. Kerber, though, hit most of what she could reach right back hard and flat, and only made half as many unforced errors.
When Serena broke again for a 2-1 lead in the final set, the American whirled and pumped her arms.
"It's Love-40 and I was not winning my serve, so I was, like, Oh, my God, I need to go there and try to talk to the chair umpire and try to ask her to ask the referee to come".
Jeļena Ostapenko advanced to the Wimbledon semifinals, where she will play against Angelique Kerber, by beating Dominika Cibulková.
Sasnovich, 24, saved four break points in the fourth game of the second set, her last stand, but could not hold. It's normal that I lost here, too.
Ostapenko hasn't dropped a set in her first five matches as she marches into the women's singles semi finals for the first time ever at the All England Lawn Tennis club in a dominating manner. She had 14 winners and 10 unforced errors, while Kerber had three winners and - this was key - zero unforced errors.
In the men's draw, defending champion Roger Federer eased into his 16th Wimbledon quarter-final with a 6-0, 7-5, 6-4 win over unseeded Adrian Mannarino of France.
Simon failed to convert a break point, then a third match point for Del Potro ended with him netting a forehand.