Melania Trump first announced she would make a solo trip to Africa in August, about seven months after Donald Trump reportedly referred to African nations as "shithole countries" in an immigration meeting.
Mrs. Trump plans to visit a hospital neonatal intensive care unit before going to the presidential palace for tea with Akufo-Addo.
She is expected to emphasize the health and education of children as part of her "Be Best" platform that she launched in May.
Mrs Trump's arrival in Accra, the Ghanaian capital, was therefore unsurprisingly subdued.
Dancers performed in the capital city of Accra for the first lady and she seemed to enjoy the moment, clapping to show her appreciation. She was welcomed at the airport with dancing and drumming, schoolchildren waving mini US and Ghanaian flags and the gift of a flower bouquet.
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Pompeo said Wednesday that the USA has already made clear that there will be humanitarian exceptions to the sanctions. The rulings of the ICJ - which is based in The Hague - are binding but the court has no power to enforce them.
Ahead of her trip, Melania said she was looking forward to visiting "four handsome and very different countries in Africa".
The White House at the time denied he had made the comments.
The trip is Trump's first major solo outing overseas as first lady. Per the pool report, "as the first lady helped pass out blankets and bears, she picked up a chubby-cheeked baby and made faces at him, to the delight of the assembled mothers and hospital officials".
She called it "an awareness campaign, dedicated to the most valuable and fragile among us - our children".
USAID and the U.S. Department of State provided more than $8 billion in assistance to 47 countries in sub-Saharan Africa in 2015.