It was a selection that gave City the green light to dominate from the opening kickoff and meant Marcus Rashford and Anthony Martial were given a thankless task up front, asked to use their pace to hit City on the counter.
Paul Pogba will not join up with France during the global break after missing the Manchester derby through injury.
The Red Devils remain eighth in the Premier League and a title challenge now looks already off the cards.
"For me, personally, to score the victor there was the biggest feeling in my career", the 21-year-old told United's official website.
Manchester United's Alexis Sanchez has been linked with a route out of the club after an underwhelming start to his United career since moving from Arsenal; the Chilean's frequent scintillating man-of-the-match moments with the North London club simply have not been replicated up North.
A 44-pass move that allowed Ilkay Gundogan in to finish off the game in City's favour, a general malaise hung over a performance from Jose Mourinho's men that offered little or nothing to the tie as a whole.
Armistice Day: Trump blasts Macron hours before Paris meeting
The two leaders early on shared an extremely friendly relationship that was on full display during a state visit in by Mr. Macron told Europe 1 radio that the "main victim" of the U.S. withdrawal from the INF accord was Europe and its security.
Manchester United continued the theme of their season by conceding first at the Etihad Stadium, but unlike recent games, found themselves up against opponents not prepared to let them back into the game. They had 6-0 wins, no pressure, relaxed.
"The most important thing is to believe, in ourselves, that we can do it".
He insisted his team were united in reality as well as in name, while saying all three of City´s goals were down to mistakes by his players.
"It's sobering to say, but we shouldn't compare Manchester United to Manchester City actually", Neville claimed.
'Of course, we missed him.
"Derbies are always tough games, but I think they're the games in which you always learn the most. I was on the bench for that game and I was itching to get on", he said. The one thing he hasn't delivered answers to are the same issues which have plagued United so far this season and leave them languishing outside the top four.