If this happens, it will leave a hole in the world of daytime TV hosted by a charismatic woman.
Ellen told The New York Times she hasn't renewed an agreement for her self-titled talk show, which is under contract until 2020.
In a new interview with The New York Times, readers get a glimpse inside 60-year-old DeGeneres and 45-year-old de Rossi's marriage, when de Rossi takes a fall off a horse and gets a concussion.
Ellen DeGeneres has hosted her daytime talk show, "The Ellen DeGeneres Show", for over 15 years, and that run could be ending soon. "There are other things she could tackle", de Rossi said.
The Times said that she has received conflicting advice, and changed her mind several times.
Meanwhile, de Rossi, 45, defended her stance, saying she wants to see her aging wife explore all her options.
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DeGeneres though is aware of her the power of her talkshow's positivity.
Given these conflicting opinions, DeGeneres nearly didn't extend her contract, according to The New York Times. She voiced the title character in the 2016 animated film "Finding Dory", reprising the role from 2003's "Finding Nemo". "There's a tiny, tiny bit of difference".
De Rossi also suggested that if DeGeneres stops doing the show, she may go to radio or start her own podcast.
Ellen also has a comedy special coming out on Netflix (December 18th) that has a sly, tongue-in-cheek title: Relatable.
Ellen DeGeneres said she's considering leaving "The Ellen DeGeneres Show". We will find out her decision in two years.
"I wanted to show all of me", DeGeneres added. "There's more range of emotion [in Relatable]". She wants to combine her old self with her new self.