The win over Brighton made it seven wins in a row for The Red Devils, and they're yet to lose since the appointment of Ole Gunnar Solskjaer as interim manager.
"I'm hoping for a thrilling contest that ends 3-2 and I believe Arsenal's firepower will be enough to inflict a first defeat on Solskjaer".
Sanchez's return to the Emirates will no doubt add some extra spice to an already flaming hot encounter, although he hasn't gotten much game time since Solskjaer's arrival, starting just once in the previous round of the FA Cup against Reading.
Arsenal and Manchester United will go head to head on Thursday in a giant FA Cup fourth-round clash.
Asked if De Gea is being rotated, Solskjaer told MUTV: 'Yes, Sergio is a fantastic goalkeeper we are a team. The Red Devils have won all their games under the Norwegian, but we face another tough test in the FA Cup.
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And United can get the win.
"I'm here, I'm ready for any challenge and I'm training with the best players in the world, with the best team in the world".
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Come Friday there are likely to be relegated to a side show on the substitutes bench with both clubs left to regret the massive salaries they signed up to a year ago. "I spoke to him on many occasions and I also know that he's going to take it with both hands and try and grab hold of that for as long as he can and hopefully it'll be a long, long time".
What Solskjaer is doing right now is working, so any change to the rhythm could have a negative effect when the Premier League starts again.
"With the French connection they had - [Thierry] Henry, [Patrick] Vieira, [Robert] Pires, [Emmanuel] Petit - they were just great games you were looking forward to".