Barcelona are about to embark on a gruelling run of fixtures with league games at Athletic Bilbao, Sevilla and then Real in the next four weeks, as well as two Champions League ties against Lyon thrown in the mix.
Barcelona forward Ousmane Dembele is unlikely to be fit for the game, as he is still recovering from a hamstring injury.
Messi did not take part in full training on Monday, but returned to join his team-mates on Tuesday for their final session.
Barcelona face Real Madrid in the first leg of their quarter-final showdown next week.
'The most important thing is whether the player tells you he is ready or not.
Are Kylie Jenner and Travis Scott Thinking About Baby No. 2?
Cape Town - Kylie Jenner trolled herself, and the entire world, when she joked about a second baby announcement. It's a lot for her sisters to travel and leave their families for that short of a time.
But Madrid are in good form under Santiago Solari, having won their past five games in a row in all competitions, while Barca were held 2-2 by Valencia last time out.
Asked at the prematch news conference in Madrid whether he wanted his fellow Argentine to be available for Wednesday's game, Solari said it would be best for the spectacle for Messi to feature. "The calendar is very complicated", he said.
Valverde said he would make a final decision on Messi after consulting with the player and the club's medical team.
However, the dropped points leaves the door open for Atletico Madrid to close the gap on the La Liga leaders, who they trail by six ahead of their match with Real Betis on Sunday. Although the statistic is quite staggering, Ernesto Valverde, will be wary of what the over dependency on one man can cost as we progress to the end of the season.
Madrid supporters will need no reminding of Suarez's impact in the most recent encounter between these sides, as he scored a hat-trick in October's 5-1 demolition at this ground. "We are expecting them at their best".