In a seemingly grave moment, he translated the phrase as an inspiring call to unity in troubled times.
And although he gave a cheeky speech about the influence of the movie while also slipping in a few jokes, Noah saved his best dig of the night for the fellow South Africans watching at home.
While the guests cheered on, Black Twitter left in stitches not buy Noah's tale but the true meaning of the Xhosa phrase which loosely translated "White people don't know I'm lying".
This was met with respectful clapping from the audience. "Trevor Noah just pulled off a heist, and they clapped for him", one South African tweeted.
Atlas Air cargo jet crashes near Baytown, Texas, today
The plane then flew for China Airlines and LAN Airlines and ended its service as a passenger jet in 2014. FAA spokesperson Lynn Lunsford said that initial reports indicated that three people were on board.
Did you catch Trevor Noah's Black Panther joke? But when a powerful old enemy reappears, T'Challa's mettle as king-and Black Panther-is tested when he is drawn into a formidable conflict that puts the fate of Wakanda and the entire world at risk.
Noah pointed out that since the release of the film, people have started greeting him by saying "Wakanda Forever".
While Black Panther did not win the best picture award, it won best original score, best production design and best costume design at Sunday's 91st Academy Awards ceremony.
Trevor said: 'Even Mel Gibson said to me Wakanda Forever, he said something else after, but the Wakanda Part was nice'.