It took a bulldozing run from Tuilagi to push Wales back and Farrell was able to kick a penalty, but waves of attacks from the red shirts eventually took their toll on Eddie Jones' men.
His withdrawal coincided with the collapse of his team as rattled England lost their heads.
"We are definitely going to learn from this", he said.
"Let's take it back to Ireland (England's opening win in Dublin) when people were talking about how we were wearing our hearts on our sleeves". I wouldn't say it means more to them.
This match reminds me of 2013 when England were coming for the Grand Slam and Wales put 30 points on them.
GoFundMe campaigns to raise money for R. Kelly's bond removed from site
He did not say if it was the same 14-year-old girl who he alleged was in the first video he turned over to the authorities. One vehicle parked near the jail reportedly played 1996 hit, " I Believe I Can Fly " while a bystander loudly sang along.
It also put the Grand Slam in sight, with visits to come from France in two weeks and, in the last round, defending champions Ireland, a fitting finale. It all conspired to give relief to England, who grabbed their first try-scoring chance, from a Welsh turnover.
The defence showed its true colors in an extended injury time when England threw an 11-man scrum at Wales, which just held out to trail 10-3. "England just seemed to stop playing in the second half".
Somehow it carried as much oomph as the staggering impact made by the outstanding Wales flanker Josh Navidi in a pack who used the pick-and-go in attack, and nearly maniacal tackling in defence, to keep England's Billy Vunipola at bay, and find gaps in the wide channels when it counted. Anscombe kicked Wales to within a point, while Sinckler, whom Gatland called an "emotional timebomb" in the run-up for brain fades, was yanked off.
Asked whether he'd be ready to return for the Italy game Borthwick said: "I expect him to continue to be monitored on a day-by-day basis and progress. he is not fit for this Saturday and right now I am not looking beyond that".
Like his coach, Biggar thrives on the big occasion and duly delivered a cameo for the ages, helping to set up the late tries for Cory Hill and, with a perfectly-placed spiralling kick to the corner, Josh Adams, that won the match. The try was his last act on the field. Adams then applied the finishing touch from a cross-kick, which was once again from Biggar.
Moments later, Wales were walking a lap of honor.