"Captain Marvel" took in $302 million internationally, giving it an estimated global opening weekend of $455 million - the sixth highest global debut of all time.
The film, which is Marvel Studios' first female-led feature, wrapped up the weekend with $153 million at the North American domestic box office.
Co-starring Samuel L. Jackson, Ben Mendelsohn, Jude Law and Annette Bening, Captain Marvel hauled in $13.6 million on 862 screens and $15.1 million including Wednesday night previews in Oz, 30 per cent ahead of Black Panther's first weekend. And given these huge numbers, it looks like Captain Marvel will end up having one of the largest worldwide openings of all time.
The 29-year-old actress - who stars as the titular character in the new Marvel movie - wants the film to trigger discussions about diversity within the film business and beyond. "Even better following International Women's Day that these girls get to meet a real role model and hero".
In the US the film garnered an estimated $153 million during its debut.
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Meanwhile, Captain America: Civil War managed to pull in an impressive $179 million during its opening weekend at the box office.
"Captain Marvel" arrives almost a year after the cliffhanger ending to "Avengers: Infinity War", which teased that the heroine is the most powerful superhero and the only one who could take on villain Thanos.
Audiences in the USA and Canada for "Captain Marvel" were 55 per cent male and 45 per cent female.
The Marvel movie's box office takings have been of particular interest to analysts, given the concerted efforts by trolls, bots and misogynists to drag down its audience review scores on Rotten Tomatoes and IMDb, and "dislike" any related videos on YouTube. Yes, Brie Larson was serving away popcorn and soda to movie watchers.
"Captain Marvel" is the 21st Marvel Studios film, going back to 2008, a year before Disney bought the franchise.